2019-07-01 10:31:162025-05-15 03:13:11
locus
BSU15890
BSU_15890
outlinks
bsu
BSU15890
BSU_15890
Gene
Phenotypes of a mutant
essential [Pubmed|24224907,12682299]
depletion results in sporulation deficiency (via [[protein|SpoIIR]]) [Pubmed|22111992]
a ts mutant forms an abberant Z-ring and has a [SW|cell division] defect [Pubmed|24224907]
essential [Pubmed|24224907,12682299]
depletion results in sporulation deficiency (via [[protein|SpoIIR]]) [Pubmed|22111992]
a ts mutant forms an abberant Z-ring and has a [SW|cell division] defect [Pubmed|24224907]
depletion results in accumulation of malonyl-CoA and of long-chain-ACPs [pubmed|32671874]
The protein
Catalyzed reaction/ biological activity
catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)
catalyzes the synthesis of the intermediate fatty acyl-phosphate (acyl-PO4)
fatty acyl-[ACP] + phosphate --> acyl phosphate + holo-[ACP] (according to UniProt)
The protein
Protein family
plsX family (according to Swiss-Prot)
plsX family (single member, according to UniProt)
The protein
Structure
[PDB|1VI1] [Pubmed|16021622]
[PDB|6A1K]
[PDB|1VI1] [Pubmed|16021622]
[PDB|6A1K] [pubmed|31453380]
The protein
[SW|Localization]
uniformly distributed on the membrane of most cells, but occasionally appears as membrane foci as well [Pubmed|26816052]
in the presence of daptomycin, PlsX delocalizes from the membrane to the cytoplasm [Pubmed|27791134]
localizes to regions of increased fluidity in the membrane (via a short amphipathic α-peptide) [pubmed|31453380,31925177]
uniformly distributed on the membrane of most cells, but occasionally appears as membrane foci as well [Pubmed|26816052]
in the presence of daptomycin, PlsX delocalizes from the membrane to the cytoplasm [Pubmed|27791134]
References